Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution.

Comparison of the efficacy of preservative free ipratropium bromide and Atrovent nebuliser solution.

The paradoxical bronchoconstriction observed with commercially available isotonic ipratropium bromide nebuliser solution (Atrovent) in patients with asthma results from an adverse reaction to the preservatives, benzalkonium chloride and ethylenediaminetetra-acetic acid (EDTA). The airway response to inhaled Atrovent and preservative free ipratropium bromide nebuliser solutions has been examined...

Ipratropium bromide bronchodilator solution.

Comparison of the effects of inhaled ipratropium bromide and salbutamol on the bronchoconstrictor

A double blind, placebo controlled compa-rison was made of the effects of nebulised ipratropium bromide (0O05 and 0-5 mg) and salbutamol (0-25 and 2-5 mg) on lung function and the airway response to hyperventilation in eight normal subjects. Both agents at both doses caused similar baseline bronchodilatation, confirming the presence of resting bronchomotor tone. The overall mean increases as pe...

Ineffectiveness of ipratropium bromide in acute bronchiolitis.

In a double blind randomised trial, we found no evidence that nebulised ipratropium bromide was of clinical benefit in acute bronchiolitis.

Effects of Inhaled Albuterol and Ipratropium Bromide

Study objective: Systemic administration of P-agonist and anticholinergic drugs markedly impair normal autonomic heart rate control. The purpose of this study was to quantify and compare the effects of therapeutic doses of inhaled albuterol and ipratropium on autonomic control of the cardiovascular system. Design: Randomized, double-blind, placebo-controlled, crossover design study. Setting: Te...